Small intestine motility dysfunction is an issue in small intestine bacterial overgrowth (SIBO). Agents that promote stomach emptying can also be helpful in treating and preventing relapse of SIBO. Ginger modulates serotonin signaling by 5-HTP4 stimulation. This is also the mechanism of action of the pro kinetic agent Resolor (Proclapride) used in preventing SIBO. Resolor promotes multiple MMC waves vs. low dose erythromycin which stimulates one MMC wave. Gingerols have been found to promote gastroduodenal emptying rate and motility in (24) healthy volunteers and the effect of a ginger rhizome extract (2 x 100 mg) was studied on fasting and postprandial gastroduodenal motility with stationary manometry.
Artificial colors are small molecule chemicals and the proper way to measure antibodies to such chemicals is by testing the chemical bound to human tissue. These chemicals and/or their metabolites can trigger inflammatory cytokines. This results in proteins that accumulate in the gastrointestinal tract and cause inflammation. This inflammation can then lead to the opening of the tight junctions and may then lead to intestinal permeability and trigger autoimmunity or relapse in SIBO.
Low FODMAP eating plan while either treating or maintaining your SIBO results often contain gums. Gums are most often used as replacement for wheat gluten and are in many gluten free products. They are also found in many processed foods in the form of emulsifiers, stabilizers, thickeners, food additives, glazing agents and even in fire retardant gelling agents and often act as endocrine disrupting chemicals (EDCs).
Folate is an important B vitamin that is naturally present in a variety of foods. The term "folic acid" is often used interchangeably for folate, but folic acid is actually a man-made chemical that can cause problems in individuals with an MTHFR gene mutation. Folic acid is added to many processed foods such as breads, cereals, etc.
Have you heard of bone broth? Perhaps you have seen it touted as one of the latest health trends? Or maybe you are familiar with the healing properties of bone broth that are well-recognized by the Paleo and GAPS communities?