Small intestine motility dysfunction is an issue in small intestine bacterial overgrowth (SIBO). Agents that promote stomach emptying can also be helpful in treating and preventing relapse of SIBO. Ginger modulates serotonin signaling by 5-HTP4 stimulation. This is also the mechanism of action of the pro kinetic agent Resolor (Proclapride) used in preventing SIBO. Resolor promotes multiple MMC waves vs. low dose erythromycin which stimulates one MMC wave. Gingerols have been found to promote gastroduodenal emptying rate and motility in (24) healthy volunteers and the effect of a ginger rhizome extract (2 x 100 mg) was studied on fasting and postprandial gastroduodenal motility with stationary manometry.